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Bioorg Med Chem Lett. 1998 Oct 6;8(19):2695-8.

Novel protein kinase C inhibitors: alpha-terthiophene derivatives.

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1
Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907-1333, USA.

Abstract

A series of alpha-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC50 < 1 microM). alpha-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase.

PMID:
9873605
[Indexed for MEDLINE]

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