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Bioorg Med Chem Lett. 1998 Oct 6;8(19):2685-8.

Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.

Author information

1
College of Pharmacy, University of Michigan, Ann Arbor 48109, USA.

Abstract

A pair of diastereomeric peptidomimetics based upon opioid receptor-binding pharmacophore models derived for a series of opioid tetrapeptides was synthesized. Both analogues display high opioid receptor affinity, moderate selectivity for the mu opioid receptor, and are potent, full agonists.

PMID:
9873603
DOI:
10.1016/s0960-894x(98)00472-7
[Indexed for MEDLINE]

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