Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1998 Sep 22;8(18):2467-72.

Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.

Author information

1
Department of Medicinal Chemistry, Merck & Co., West Point, PA 19486, USA.

Abstract

Benign prostatic hyperplasia can be managed pharmacologically with alpha-1 adrenergic receptor antagonists. Agents that demonstrate selectivity for the alpha-1a receptor subtype may offer advantages in clinical applications with respect to hypotensive side effects. The N-alkylated saccharins reported here represent a new class of subtype selective alpha-1a adrenergic receptor antagonists which demonstrate potent effects on prostate function in vivo and are devoid of blood pressure side effects.

PMID:
9873563
DOI:
10.1016/s0960-894x(98)00446-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center