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Bioorg Med Chem Lett. 1998 Sep 8;8(17):2351-6.

"Cut and combine": an easy membrane-supported combinatorial synthesis technique.

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AG Molecular Recognition, GBF, Braunschweig, Germany.


A combinatorial synthesis process involving sequential cycles of cutting a membrane support into pieces and combining these into groups and subjecting the groups to simultaneous solid-phase chemical reactions is demonstrated by the rapid assembly of four hundred N-terminally biotinylated, soluble, octameric peptide pools. Index patterns printed onto the synthesis membrane allowed a direct identification of the compounds. These were used to study protein kinase substrate selection in a parallel microplate adapted 32P-phosphorylation assay with subsequent spotting on a biotin-capture membrane.

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