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Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20.

Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library.

Author information

1
Department of Biology, Pharmacopeia, Inc., Princeton, NJ 08540, USA.

Abstract

An encoded 13,020-member combinatorial library was synthesized containing a statine core. Evaluation of this library with plasmepsin II, an aspartyl protease required for hemoglobin metabolism in the malaria parasite, led to the identification of potent and selective inhibitors as well as novel structure-activity relationships.

PMID:
9873534
DOI:
10.1016/s0960-894x(98)00419-3
[Indexed for MEDLINE]

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