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Bioorg Med Chem Lett. 1998 Aug 18;8(16):2235-40.

Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors.

Author information

1
Berlex Biosciences, Richmond, CA 94804, USA.

Abstract

The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8-dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.

PMID:
9873520
DOI:
10.1016/s0960-894x(98)00386-2
[Indexed for MEDLINE]

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