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Bioorg Med Chem Lett. 1998 Aug 18;8(16):2223-6.

Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.

Author information

1
Department of Chemistry, Clemson University, SC 29634-1905, USA.

Abstract

An enantioselective synthesis of the (1'S,2'R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC (3). Pharmacology, in vivo and in vitro, indicate (3) to be one of the most potent traditional cannabinoids known.

PMID:
9873517
DOI:
10.1016/s0960-894x(98)00385-0
[Indexed for MEDLINE]

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