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Bioorg Med Chem Lett. 1998 Aug 18;8(16):2173-8.

Conformationally restricted analogues of nicotine and anabasine.

Author information

1
SIBIA Neurosciences Inc., La Jolla, CA 92037, USA.

Abstract

A series of conformationally restricted analogues of nicotine has been synthesized and evaluated as agonists of neuronal acetylcholine receptors. Compound 2 (SIB-1663), which selectively activated human recombinant alpha 2 beta 4 and alpha 4 beta 4 nAChRs, was shown to be active in animal models of Parkinson's disease and pain.

PMID:
9873508
DOI:
10.1016/s0960-894x(98)00394-1
[Indexed for MEDLINE]

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