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Bioorg Med Chem Lett. 1998 Aug 18;8(16):2103-8.

Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation.

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1
Hybridon, Inc., Cambridge, MA 02139, USA.

Abstract

We have synthesized and studied the effects of phosphorothioate (PS) oligodeoxyribonucleotide (DNA) and oligoribonucleotides (RNA, 2'-O-methyl-RNA and 2'-5'-RNA) on complement activation and prolongation of activated partial thromboplastin time (aPTT) in vitro. These results suggest that a PS-DNA prolongs aPTT, and inhibits complement lysis more than do the PS-RNA analogs.

PMID:
9873494
[Indexed for MEDLINE]

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