Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80.

Design and synthesis of conformationally-constrained MMP inhibitors.

Author information

1
Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA.

Abstract

A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety.

PMID:
9873489
DOI:
10.1016/s0960-894x(98)00370-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center