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Bioorg Med Chem Lett. 1998 Aug 4;8(15):1985-90.

Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid.

Author information

1
Eli Lilly and Company, Indianapolis, Indiana 46285, USA.

Abstract

A series of N1-substituted derivatives of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) has been prepared as constrained analogs of gamma-substituted glutamic acids and examined for their effects at recombinant metabotropic glutamate receptor (mGluR) subtypes in vitro. Appropriate substitution of the N1 position of 2R,4R-APDC resulted in the identification of a number of selective group II mGluR antagonists.

PMID:
9873471
DOI:
10.1016/s0960-894x(98)00352-7
[Indexed for MEDLINE]

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