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Bioorg Med Chem Lett. 1998 Jul 21;8(14):1791-6.

Development of new chromanol antagonists of leukotriene D4.

Author information

1
Central Research Division, Pfizer Inc., Groton, CT 06340, USA.

Abstract

By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).

PMID:
9873435
DOI:
10.1016/s0960-894x(98)00273-x
[Indexed for MEDLINE]

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