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Bioorg Med Chem Lett. 1998 Jul 7;8(13):1767-70.

The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.

Author information

1
Novo Nordisk A/S, Måløv, Denmark.

Abstract

The synthesis and purinergic receptor binding of novel adenosine A3 ligands is described. Many selective A3 receptor agonists e.g. N-(3-iodobenzyl)adenosine-5'-methyluronamide (IB-MECA) contain a 4'-ribosylalkylamide moiety. We found that this amide and other 4'-functional groups could be replaced with an isosteric isoxazole, and the target molecules retained potent binding to the recombinant human A3 receptor.

PMID:
9873431
DOI:
10.1016/s0960-894x(98)00302-3
[Indexed for MEDLINE]

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