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Bioorg Med Chem Lett. 1998 Jul 7;8(13):1745-50.

Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents.

Author information

1
DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500, USA.

Abstract

Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.

PMID:
9873427
DOI:
10.1016/s0960-894x(98)00308-4
[Indexed for MEDLINE]

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