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Bioorg Med Chem Lett. 1998 Jul 7;8(13):1629-34.

A new series of cyclic amino acids as inhibitors of S-adenosyl L-methionine synthetase.

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Laboratoire de chimie bioorganique, U.M.R. 6519, U.F.R. Sciences de Reims, France.


Optically active 3-amino-3-(tetrahydrofuranyl) carboxylic acid, 3-amino-3-(tetrahydrothienyl) carboxylic acid and their corresponding six membered ring analogues have been synthesised and examined as potential inhibitors of the enzyme S-adenosylmethionine (AdoMet) synthetase. The kinetic behaviour of these compounds was studied using recombinant rat liver AdoMet synthetase (alpha-isoform) fractionated from E. coli transformed with the plasmid pSSRL-T7N. All the compounds tested were competitive inhibitors of the enzyme with respect to L-methionine.

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