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Bioorg Med Chem Lett. 1998 Jun 16;8(12):1511-6.

Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Author information

1
Medivir AB, Huddinge, Sweden. christer.sahlberg@medivir.se

Abstract

A series of potent specific HIV-1 RT inhibitory compounds is described. The compounds are urea analogs of PETT (PhenylEthylThiazoleThiourea) derivatives and the series includes derivatives with an ethyl linker (1-6) and conformationally restricted analogs (7-13). The antiviral activity is determined both at the RT level and in cell culture on both native and mutant forms of HIV-1. Many compounds display activity in the nM range against wt-RT.

PMID:
9873380
DOI:
10.1016/s0960-894x(98)00249-2
[Indexed for MEDLINE]

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