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Bioorg Med Chem Lett. 1998 Jun 16;8(12):1477-82.

Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases).

Author information

1
Institute for Drug Research, Budapest, Hungary. h13770baj@ella.hu

Abstract

Inhibition of interleukin-1 beta converting enzyme (ICE), apopain, papain, thrombin and trypsin with substrate like peptidyl L- and D-alpha-aldehydes and their L-beta-homo-aldehyde analogues was investigated. The L-beta-homo-aspartals appear to be specific inhibitors for ICE and its homologues; the other enzymes were not inhibited with such L-beta-homo aldehydes. Papain shows tolerance for D-residues at P1 depending on their chiral stability.

PMID:
9873373
DOI:
10.1016/s0960-894x(98)00244-3
[Indexed for MEDLINE]

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