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Nature. 1998 Dec 17;396(6712):699-703.

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer.

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  • 1Department of Molecular Oncology, Molecular Biology, and Immunology, Genentech, Inc., South San Francisco, California 94080, USA.

Abstract

Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces apoptosis (programmed cell death) in target cells through the death receptor Fas/Apol/CD95. One important role of FasL and Fas is to mediate immune-cytotoxic killing of cells that are potentially harmful to the organism, such as virus-infected or tumour cells. Here we report the discovery of a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds to FasL and inhibits FasL-induced apoptosis. The DcR3 gene was amplified in about half of 35 primary lung and colon tumours studied, and DcR3 messenger RNA was expressed in malignant tissue. Thus, certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL.

PMID:
9872321
DOI:
10.1038/25387
[PubMed - indexed for MEDLINE]
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