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Bioorg Med Chem Lett. 1998 May 19;8(10):1237-42.

Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis-sulfonamide dihydropyrones.

Author information

1
Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.

Abstract

Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-related sulfonamide group. Selected bis-sulfonamide dihydropyrone analogues display high HIV protease inhibitory activity.

PMID:
9871742
DOI:
10.1016/s0960-894x(98)00197-8
[Indexed for MEDLINE]

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