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Bioorg Med Chem Lett. 1998 May 19;8(10):1163-8.

The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.

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1
Wyeth-Ayerst Research, Pearl River, New York 10965, USA.

Abstract

A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).

PMID:
9871728
DOI:
10.1016/s0960-894x(98)00186-3
[Indexed for MEDLINE]

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