Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1998 May 19;8(10):1157-62.

Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.

Author information

1
Affymax Research Institute, Santa Clara, CA 95051, USA.

Abstract

A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal alpha-mercaptoketone or alpha-mercaptoalcohol in the zinc binding domain of a series of inhibitors led to compounds exhibiting low nanomolar activity against collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).

PMID:
9871727
DOI:
10.1016/s0960-894x(98)00185-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center