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Bioorg Med Chem Lett. 1998 Feb 17;8(4):345-50.

Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.

Author information

1
Department of Chemistry, University of Toronto, Erindale College, Mississauga, Ontario, Canada.

Abstract

A series of naphthalenebis(difluoromethylenephosphonates) were prepared and compared to their monosubstituted counterparts as inhibitors of the protein phosphatases, PTP1B, CD45 and PP2A. In general, the bissubstituted compounds were better inhibitors than the mono derivatives and some of these are among the most potent, nonpeptidyl inhibitors of protein tyrosine phosphatases, PTP1B and CD45, reported to date.

PMID:
9871682
DOI:
10.1016/s0960-894x(98)00027-4
[Indexed for MEDLINE]

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