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Bioorg Med Chem Lett. 1998 Feb 3;8(3):281-4.

Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist.

Author information

1
Central Research Division, Pfizer Inc., Groton, CT 06340, USA.

Abstract

The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses.

PMID:
9871670
DOI:
10.1016/s0960-894x(98)00012-2
[Indexed for MEDLINE]

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