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Bioorg Med Chem Lett. 1998 Feb 3;8(3):209-14.

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

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1
CV Therapeutics Inc. Palo Alto, CA 94304, USA.

Abstract

Potent inhibitors of the 20S proteasome that contain a novel indanone head group coupled to di and tripeptides are described. These compounds are the first proteasome inhibitors have demonstrated high selectivity for the chymotrypsin-like activity of the 20S proteasome.

PMID:
9871656
DOI:
10.1016/s0960-894x(98)00015-8
[Indexed for MEDLINE]

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