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Bioorg Med Chem Lett. 1998 Jan 20;8(2):175-8.

Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles.

Author information

1
Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426, USA.

Abstract

The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported.

PMID:
9871649
DOI:
10.1016/s0960-894x(97)10206-2
[Indexed for MEDLINE]

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