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Bioorg Med Chem Lett. 1998 Jan 6;8(1):23-8.

Hydroxamate-based inhibitors of low affinity IgE receptor (CD23) processing.

Author information

1
SmithKline Beecham Pharmaceuticals, Epsom, Surrey, UK.

Abstract

A series of hydroxamic acids related to the non-selective matrix metalloprotease inhibitor Batimastat is described, which inhibits the proteolytic cleavage of the low affinity IgE receptor from cell membrane preparations. Limited SAR studies suggest that the structural requirements for effective inhibition are distinct from those required for the inhibition of collagenase.

PMID:
9871622
DOI:
10.1016/s0960-894x(97)10148-2
[Indexed for MEDLINE]

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