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Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6.

Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12.

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  • 1Department of Chemistry, Cornell University, Ithaca, NY 14853-1301, USA.

Abstract

A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.

PMID:
9871618
[PubMed - indexed for MEDLINE]
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