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Bioorg Med Chem Lett. 1998 Mar 17;8(6):687-90.

Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

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1
Department of Chemistry, University of Illinois at Chicago 60607, USA.

Abstract

Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

PMID:
9871583
DOI:
10.1016/s0960-894x(98)00098-5
[Indexed for MEDLINE]

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