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Bioorg Med Chem Lett. 1998 Apr 7;8(7):811-6.

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.

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  • 1Welsh School of Pharmacy, University of Wales Cardiff, UK.


In this paper we describe an approach to selectively deliver compounds to trypanosomes using an adenosine transporter which is unique to the trypanosome. Various polyamine analogues have been attached to known substrates of this adenosine transporter. The compounds prepared interact specifically with the adenosine transporter, some with a similar efficiency to berenil, a known substrate.

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