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Bioorg Med Chem Lett. 1998 Apr 21;8(8):983-8.

Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.

Author information

1
R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA.

Abstract

We synthesized 20 and 21 as conformationally constrained analogues of the dopamine receptor antagonist SKF-83742, as well as analogues 6-9, 16, and 18-22. Although 20 and 21 were inactive, 7, 9, and 19 showed strong binding to D-1, D-2, S-2, and alpha-1 receptors, as well as antipsychotic activity in vivo.

PMID:
9871525
DOI:
10.1016/s0960-894x(98)00138-3
[Indexed for MEDLINE]

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