Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1998 Apr 21;8(8):979-82.

Structure based design: novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors.

Author information

1
Department of Chemistry, University of Illinois at Chicago 60607, USA.

Abstract

A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors.

PMID:
9871524
DOI:
10.1016/s0960-894x(98)00139-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center