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Bioorg Med Chem Lett. 1998 Apr 21;8(8):931-4.

Novel HIV-protease inhibitors containing beta-hydroxyether and -thioether dipeptide isostere surrogates: modification of the P3 ligand.

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1
Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.

Abstract

Studies involving modifications to the P3 position of previously described HIV-protease inhibitors containing beta-hydroxyether and thioether dipeptide isostere replacements led to the discovery of pseudopeptides 8o and 8p with improved antiviral activities.

PMID:
9871514
DOI:
10.1016/s0960-894x(98)00144-9
[Indexed for MEDLINE]

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