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Bioorg Med Chem Lett. 1998 Apr 21;8(8):913-8.

Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.

Author information

1
Department of Medicinal Chemistry, Green Cross Research Laboratories, Osaka, Japan.

Erratum in

  • Bioorg Med Chem Lett 1998 Jul 7;8(13):1778.

Abstract

Peptidyl difluoromethylene ketone derivatives were designed to take advantage of probable additional interactions with the S' subsite of human heart chymase. They showed potent inhibitory activities against human heart chymase and were more efficient than bovine chymotrypsin.

PMID:
9871511
DOI:
10.1016/s0960-894x(98)00131-0
[Indexed for MEDLINE]

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