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Arch Ophthalmol. 1998 Dec;116(12):1597-601.

Interferon-induced protein 10 and interleukin 8. C-X-C chemokines present in proliferative diabetic retinopathy.

Author information

1
Department of Ophthalmology, University of Michigan, Ann Arbor, USA.

Abstract

OBJECTIVE:

To determine vitreous levels of interleukin 8 (IL-8) and interferon-induced protein 10 (IP-10), which are members of the C-X-C chemokine family that promote and inhibit neovascularization, respectively.

METHODS:

We measured the levels of IL-8 and IP-10 by specific enzyme-linked immunosorbent assays in the vitreous from 30 patients with proliferative diabetic retinopathy (PDR) and 10 control patients undergoing vitrectomy for idiopathic macular holes or idiopathic macular puckers.

RESULTS:

Detectable levels of IL-8 were found in 23 of 24 patients with active PDR, 4 of 6 patients with inactive PDR, and 6 of 10 controls. Levels of IL-8 were significantly increased in vitreous samples from the patients with active PDR (P = .02) when compared with vitreous samples from the controls. The IL-8 levels detected in vitreous samples from patients with inactive PDR were not significantly elevated over those found in the control samples. Interferon-induced protein 10 was detected in the vitreous samples from 23 of 24 patients with active PDR, all patients with inactive PDR, and 9 of 10 controls. Significant elevations of IP-10 were measured in samples from patients with active PDR (P = .004) and in those with inactive PDR (P = .00) over those from controls. In addition, levels of IP-10 were significantly elevated in vitreous samples from patients with inactive PDR compared with vitreous samples from patients with active PDR (P = .02).

CONCLUSION:

Both IL-8 and IP-10 participate in the pathogenesis of PDR.

PMID:
9869787
DOI:
10.1001/archopht.116.12.1597
[Indexed for MEDLINE]

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