Format

Send to

Choose Destination
See comment in PubMed Commons below
Genes Dev. 1998 Dec 15;12(24):3815-20.

Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila.

Author information

1
Banting and Best Department of Medical Research, Charles H. Best Institute, University of Toronto, Ontario M5G 1L6, Canada.

Abstract

Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The interaction domains map to a small region of Vg that is essential for Vg-mediated gene activation and to the carboxy-terminal half of Sd. Our observations indicate that Vg and Sd function coordinately to control the expression of genes required for wing development, which implies that Vg is a tissue-specific transcriptional intermediary factor of Sd.

PMID:
9869635
PMCID:
PMC317270
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center