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Int J Tuberc Lung Dis. 1998 Dec;2(12):984-8.

Preventive therapy for tuberculosis in Western Australia.

Author information

1
Tuberculosis Control Programme, Perth Chest Clinic, Western Australia, Australia.

Abstract

SETTING:

State Tuberculosis Control Programme, Western Australia.

OBJECTIVE:

To ascertain baseline information, applicability and efficacy of preventive therapy for tuberculosis (TB) under indirectly supervised treatment in Western Australia.

DESIGN:

Retrospective analyses of records of persons with TB infection who were prescribed preventive therapy for the period 1993-1996 inclusive, using simple descriptive statistics.

RESULTS:

Preventive therapy was given to 411 persons after screening for TB due to on-arrival migrant surveillance (269), contact tracing (59), tuberculin surveys (59) and other reasons (24). Six-month isoniazid monotherapy (HMT) was prescribed for 403 and multidrug regimens for the remaining eight. Excepting 34 whose compliance was unknown, varying degrees of treatment non-adherence were found in 90 (24%) of the remaining 369 persons given HMT, including 36 (10%) with under five months of total medication. Minor adverse drug effects occurred in 32 (9%) subjects and contributed to the non-adherence in 23 of these. One person has since developed active TB.

CONCLUSIONS:

Preventive therapy in Western Australia conformed to generally accepted guidelines. Varying degrees of non-adherence to HMT occurred in 24% of persons, but 90% completed adequate therapy under indirect supervision. Non-adherence is significantly related to adverse drug effects.

PMID:
9869113
[Indexed for MEDLINE]

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