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Clin Infect Dis. 1998 Dec;27(6):1497-507.

Interleukin-10: potential benefits and possible risks in clinical infectious diseases.

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Infectious Disease Division, Brown University School of Medicine, Providence, Rhode Island, USA.


Human interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that inhibits the synthesis of the major proinflammatory cytokines and chemokines. IL-10 is the principal TH2-type cytokine that upregulates humoral immune responses and attenuates cell-mediated immune reactions. This cytokine has a number of immunomodulatory properties that might be clinically useful in a variety of inflammatory and infectious disease states. Clinical trials with human recombinant IL-10 are already in progress. Carefully selected patients with inflammatory conditions may benefit from IL-10 therapy if concomitant infectious diseases are recognized and treated appropriately.

[Indexed for MEDLINE]

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