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Arch Pharm Res. 1998 Dec;21(6):688-91.

Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi.

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Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.


Antifungal activities of the compounds isolated from Kalopanax pictus against representative fungi of dermatomycosis were investigated using paper disc diffusion method. It was found that kalopanaxsaponins A and I were effective in inhibiting the growth of Candida albicans KCTC 1940 and Cryptococcus neoformans KCTC 7224 with minimum inhibitory concentration (MIC) of 25 micrograms/ml. It showed that antifungal activity of both compounds have strong selectivity against the fungi of dermatomycosis.

[Indexed for MEDLINE]

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