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Emerg Infect Dis. 1998 Oct-Dec;4(4):615-7.

Mutators and long-term molecular evolution of pathogenic Escherichia coli O157:H7.

Author information

1
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA. tsw1@psu.edu

Abstract

It has been proposed that an increased mutation rate (indicated by the frequency of hypermutable isolates) has facilitated the emergence of Escherichia coli O157:H7. Analysis of the divergence of 12 genes shows no evidence that the pathogen has undergone an unusually high rate of mutation and molecular evolution.

PMID:
9866737
PMCID:
PMC2640239
DOI:
10.3201/eid0404.980411
[Indexed for MEDLINE]
Free PMC Article

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