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Infect Immun. 1999 Jan;67(1):446-8.

Gamma delta T-cell function in pathogenesis of cerebral malaria in mice infected with Plasmodium berghei ANKA.

Author information

1
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison 53706, USA.

Abstract

Mice depleted of gammadelta T cells by monoclonal antibody treatment and infected with Plasmodium berghei ANKA did not develop cerebral malaria (CM). In striking contrast, delta0/0 mice infected with P. berghei developed CM despite their gammadelta T-cell deficiency. gammadelta T cells appear to be essential for the pathogenesis of CM in mice having experienced normal ontogeny but not in mice genetically deprived of gammadelta T cells from the beginning of life.

PMID:
9864254
PMCID:
PMC96335
[Indexed for MEDLINE]
Free PMC Article

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