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Gut. 1999 Jan;44(1):127-36.

Inhibitory effect of oestradiol on activation of rat hepatic stellate cells in vivo and in vitro.

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1
Second Department of Internal Medicine, School of Medicine, University of Tokushima, Tokushima, Japan.

Abstract

BACKGROUND:

Hepatic stellate cells play a key role in the pathogenesis of hepatic fibrosis.

AIMS:

To examine the inhibitory effect of oestradiol on stellate cell activation.

METHODS:

In vivo, hepatic fibrosis was induced in rats by dimethylnitrosamine or pig serum. In vitro, rat stellate cells were activated by contact with plastic dishes resulting in their transformation into myofibroblast-like cells.

RESULTS:

In the dimethylnitrosamine and pig serum models, treatment with oestradiol at gestation related doses resulted in a dose dependent suppression of hepatic fibrosis with restored content of hepatic retinyl palmitate, reduced collagen content, lower areas of stellate cells which express alpha smooth muscle actin (alpha-SMA) and desmin, and lower procollagen type I and III mRNA levels in the liver. In cultured stellate cells, oestradiol inhibited type I collagen production, alpha-SMA expression, and cell proliferation. These findings suggest that oestradiol is a potent inhibitor of stellate cell transformation.

CONCLUSION:

The antifibrogenic role of oestradiol in the liver may contribute to the sex associated differences in the progression from hepatic fibrosis to cirrhosis

PMID:
9862839
PMCID:
PMC1760074
[Indexed for MEDLINE]
Free PMC Article
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