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Psychopharmacology (Berl). 1998 Nov;140(1):38-41.

Influence of nicotine on simulator flight performance in non-smokers.

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Stanford University, School of Medicine, Department of Psychiatry, CA 94305-5550, USA.


In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior to each test, subjects received either nicotine polacrilex 2 mg or placebo gum. As expected, overall performance was significantly better after nicotine, compared to placebo (P < 0.01). Post-hoc analysis of individual flight tasks showed that nicotine improved scores on approach to landing, a task which appears to require sustained attention. We conclude that nicotine may improve late-day flight performance in non-smoking aviators.

[Indexed for MEDLINE]

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