Format

Send to

Choose Destination
Histochem Cell Biol. 1998 Dec;110(6):595-601.

CNS glia are targets for GDNF and neurturin.

Author information

1
Anatomie und Zellbiologie, Universit├Ąt Ulm, Germany.

Abstract

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two closely related growth factors reported to selectively act on distinct neuronal populations in the CNS. Both GDNF and NTN signal through a receptor complex consisting of the signal transducing subunit, Ret, and a ligand-specific binding subunit, termed GDNF family receptor (GFR)alpha-1 and GFRalpha-2, respectively. By using RT-PCR, we observed that mRNAs encoding the subunits of both receptor complexes are widely expressed throughout the developing brain, suggesting the presence of targets for these growth factors other than the ones known today. We provide evidence that these targets include glial cells.

PMID:
9860258
DOI:
10.1007/s004180050322
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center