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Ann Allergy Asthma Immunol. 1998 Nov;81(5):423-7.

A case of pathophysiologic study in Kimura's disease: measurement of cytokines and surface analysis of eosinophils.

Author information

1
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Abstract

BACKGROUND:

Kimura's disease is a rare but distinctive eosinophilic inflammatory disorder of unknown etiology; few reported case studies have focused on the immunopathologic background of this unique disease.

OBJECTIVE:

To define better the immunopathogenetic features of Kimura's disease, we attempted to quantitatively analyze values of cytokines and soluble interleukin-2 receptor (sIL-2R) in peripheral blood (PB), as well as perform surface immunophenotypic analysis of eosinophils from a Japanese patient with chronic relapsing Kimura's disease.

RESULTS:

Granulocyte macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha) and sIL-2R were elevated, and newly expressed antigens on eosinophils CD4, CD25, and HLA-DR were found to be involved in the pathophysiology of this disorder.

CONCLUSIONS:

Kimura's disease may be a disease in which activated lymphocytes release cytokines, and these released cytokines, such as GM-CSF and TNF-alpha cause eosinophil activation. These processes may be related to the pathogenesis of this disorder.

PMID:
9860034
DOI:
10.1016/S1081-1206(10)63139-0
[Indexed for MEDLINE]

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