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Am J Vet Res. 1998 Dec;59(12):1599-604.

Determination of skin concentrations of enrofloxacin in dogs with pyoderma.

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1
Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA.

Abstract

OBJECTIVE:

To compare serum and skin concentrations of enrofloxacin in dogs with pyoderma with those of clinically normal dogs and to evaluate concentrations in dogs with superficial versus deep pyoderma.

ANIMALS:

16 clinically normal dogs and 16 dogs with pyoderma.

PROCEDURE:

Enrofloxacin (approx 5 mg/kg of body weight, PO) was administered daily to all dogs. Serum samples and skin biopsy specimens were obtained on day 1 at 3 hours after drug administration and on day 3 immediately before and 3 hours after drug administration. Samples and specimens were assayed by high-performance liquid chromatography. Morphometric analysis was performed on skin biopsy specimens to determine correlation between inflammatory cells and peak tissue enrofloxacin concentration on day 1.

RESULTS:

Morphometric analysis revealed high correlation between dermal inflammatory cell count and drug concentration in dogs with pyoderma.

CONCLUSIONS:

At mean dosage of 5 mg/kg once daily, enrofloxacin tissue concentrations were significantly greater in dogs with pyoderma at 3 hours after pill administration. Enrofloxacin tissue concentration on day 3 at 3 hours after pill administration was 12.4 times the 90% minimum inhibitory concentration of enrofloxacin for Staphylococcus intermedius.

CLINICAL RELEVANCE:

In dogs with pyoderma, therapeutic tissue concentrations of enrofloxacin are reached as early as 3 hours after drug administration.

PMID:
9858413
[Indexed for MEDLINE]
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