Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger

J E Tucker; R J Winkfein; S K Murthy; J S Friedman; M A Walter; D J Demetrick; P P Schnetkamp

doi:10.1007/s004390050842

Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger

Hum Genet. 1998 Oct;103(4):411-4. doi: 10.1007/s004390050842.

Authors

J E Tucker¹, R J Winkfein, S K Murthy, J S Friedman, M A Walter, D J Demetrick, P P Schnetkamp

Affiliation

¹ Department of Biochemistry & Molecular Biology, and the MRC Group on Ion Channels/Transporters, Faculty of Medicine, University of Calgary, Canada.

PMID: 9856482
DOI: 10.1007/s004390050842

Abstract

The retinal rod Na-Ca+K exchanger is a unique calcium extrusion protein found only in the outer segments of retinal rod photoreceptors. Rod Na-Ca+K exchanger cDNA (NCKX1) has been cloned from bovine and human retinas. Here, we have used fluorescent in situ hybridization and radiation hybrid mapping to localize the human NCKX1 gene to chromosome 15q22. We have determined the genomic organization of human rod NCKX1 and found one intron in the 5' untranslated region and eight introns within the coding region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
Carrier Proteins / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 15*
Humans
Molecular Sequence Data
Sodium-Calcium Exchanger*

Substances

Carrier Proteins
Sodium-Calcium Exchanger
potassium-dependent sodium-calcium exchanger

Associated data

GENBANK/AF062922
GENBANK/AF062923
GENBANK/AF076932
GENBANK/AF076933
GENBANK/AF076934
GENBANK/AF076935
GENBANK/AF076936
GENBANK/AF076937
GENBANK/AF076938
GENBANK/AF076939
GENBANK/AF076940
GENBANK/AF076941
GENBANK/AF076942
GENBANK/AF076943
GENBANK/AF076944
GENBANK/AF076945
GENBANK/AF076946
GENBANK/AF076947
GENBANK/AF076948
GENBANK/AF076949