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Trends Cell Biol. 1998 Nov;8(11):428-31.

C1q--how many functions? How many receptors?

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Dept of Biochemistry, University of Oxford, UK.


C1, the first component of the classical pathway of complement activation is a complex of three proteins called C1q, C1r and C1s. Normally, C1q binding to aggregated IgG molecules results in activation of the classical pathway of complement. However, C1q has a number of other observed functions, not directly related to complement, that could be mediated by recently identified binding proteins acting as cell-surface receptors or soluble modulators of C1q-mediated functions. This article discusses the various activities of C1q and the evidence that these functions might be influenced by both membrane-bound and soluble C1q-binding proteins.

[Indexed for MEDLINE]

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