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Pediatr Infect Dis J. 1998 Nov;17(11):1012-5.

Candida fungemia in neonates treated with fluconazole: report of forty cases, including eight with meningitis.

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1
Department of Neonatology, Pediatric ICU, Postgraduate Medical School, Bratislava, Slovak Republic.

Abstract

PURPOSE OF THE STUDY:

To assess efficacy and safety of fluconazole in neonates with Candida fungemia.

STUDY DESIGN:

Multicenter prospective protocol of all fungemias appearing between January 1, 1993, and December 31, 1997, in four major university hospitals.

RESULTS:

Forty neonates, 28 of them with very low birth weight (<1500 g; 30.5 median gestation week), with documented Candida albicans fungemia were treated with intravenous fluconazole in a daily dosage of 6 mg/kg once daily for 6 to 48 days. Thirty-four received fluconazole as monotherapy and 6 received it in combination with amphotericin B. Thirty-two (80%) were cured; 4 of them relapsed despite at least 14 days of therapy, but they were ultimately cured without sequelae. Eight other neonates died, 4 because of fungal infection and 4 because of prematurity or hemorrhage or lung failure, with fungemia (20% overall and 10% attributable mortality). Two neonates had elevated liver enzymes during fluconazole therapy and 2 others had elevated serum creatinine during fluconazole monotherapy. In none of them did these abnormalities necessitate discontinuation of antifungal therapy. In 8 neonates fungal meningitis developed as a complication of fungemia. All but 3 fungemias were C. albicans; 3 were Candida parapsilosis.

CONCLUSIONS:

Fluconazole was safe and effective antifungal therapy even in complicated or Candida fungemia in neonates and in infants with very low birth weight.

[Indexed for MEDLINE]

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