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Pediatr Rev. 1998 Dec;19(12):423-8.

Clinical pharmacology and therapeutic drug monitoring in neonates and children.

Author information

1
Department of Pediatrics and Population Health Sciences, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada.

Abstract

From a pharmacotherapy perspective, the process of development and growth represents an unstable and dynamic condition. Age-related changes in drug absorption, distribution, and metabolism among neonates, infants, and prepubescent children create a unique situation that may increase drug toxicity of some agents and protect from toxicity of other agents. Understanding the age-related changes in drug disposition that are relevant for therapeutic response and toxicity is essential for optimizing pharmacotherapy at different stages of childhood.

PMID:
9849072
DOI:
10.1542/pir.19-12-423
[Indexed for MEDLINE]

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