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Nucleic Acids Res. 1999 Jan 1;27(1):263-7.

Recent improvements of the ProDom database of protein domain families.

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Laboratoire de Génétique Cellulaire, INRA, BP27, F-31326 Castanet-Tolosan cedex, France.


The ProDom database contains protein domain families generated from the SWISS-PROT database by automated sequence comparisons. The current version was built with a new improved procedure based on recursive PSI-BLAST homology searches. ProDom can be searched on the World Wide Web to study domain arrangements within either known families or new proteins, with the help of a user-friendly graphical interface ( Recent improvements to the ProDom server include: ProDom queries under the SRS Sequence Retrieval System; links to the PredictProtein server; phylogenetic trees and condensed multiple alignments for a better representation of large domain families, with zooming in and out capabilities. In addition, a similar server was set up to display the outcome of whole genome domain analysis as applied to 17 completed microbial genomes ( ).

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